Software packages for non-confocal adaptive optics images:

• Identify cone photoreceptors
• Segment boundaries of cone photoreceptors

In some people, AMD advances so slowly that vision loss does not occur for a long time. In others, the disease progresses faster and may lead to a loss of vision in one or both eyes. As AMD progresses, a blurred area near the center of vision is a common symptom. Over time, the blurred area may grow larger or you may develop blank spots in your central vision. Objects also may not appear to be as bright as they used to be.

Using publicly available healthy human RNA-seq datasets and a substantial subset of the GTEx project RNA-seq datasets to probe the relatedness and biological processes between the cornea, retina, RPE (choroid), and the rest of the human tissues with differential expression, clustering, and GO term enrichment tools.

The National Ophthalmic Disease Genotyping and Phenotyping Network (eyeGENE®) is a genomic medicine initiative created by the National Eye Institute (NEI), part of the National Institutes of Health (NIH), in partnership with clinics and laboratories across the vision research community. The core mission of eyeGENE® is to facilitate research into the causes and mechanisms of rare inherited eye diseases and accelerate pathways to treatments.

CDEs and Forms

Transcriptome, Genome, Epigenome, Regulome.

A database of 20,000 photographs, selected by human observers from over 200,000 photographs as those that contain a salient object. The images were subsequently segmented into "object" and "background", and the objects depicted in the photographs were labelled. Details can be found in Rosenthal et al, Journal of Vision, 2018.

Protein atomic structures from inherited eye disease were obtained by molecular modeling and/or from publicly available database of protein crystal structures. The stability of each protein molecule was evaluated from atomic level of protein structure and global landscape of possible protein stability changes was generated for any missense mutation.

Most LASIK studies used tools, such as questionnaires, to assess visual symptoms, but only after the surgery. The Patient-Reported Outcomes with LASIK (PROWL)disclaimer icon studies in the LQOLCP assessed visual symptoms both before and after their LASIK surgery to identify changes over time. The studies also measured the impact symptoms directly had on performing usual activities, which had not previously been done.

Deep metadata mining, rigorous quality control analysis, differential gene expression testing, and deep learning based batch effect correction in a unified bioinformatic framework allow the universe of retina single cell expression information to be analyzed in one location.